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This project investigates how hyperthermia – increasing one’s body temperature – can be used as a novel treatment for depression.
In a previous, double-blind trial, researchers from the Center evaluated participants with depression using the Hamilton Depression Rating Scale (HDRS) and found that 60 percent of them had an antidepressant response, and 40 percent met the criteria for remission of depression during at least one assessment after having received the treatment. In addition, hyperthermia induced effects on the immune system that predicted antidepressant response.
Researchers involved in this line of work hope to find complementary and faster-acting treatments for depression than the treatments currently in use. Future research will include further exploration of the efficacy of hyperthermia as a viable treatment for depression and will seek to better understand the role of the immune system in this novel treatment modality.