Be a Research Participant in The Asthma and Brain Health Study

About the Study:

Lead Researcher: Dr. Melissa Rosenkranz

How many people will be in the study? 100

Arrangements as needed for each visit:

• For visits longer than 4 hours, you will be given a meal and/or snacks.
• If needed, childcare assistance may be provided during study visits.
• Transportation assistance will be provided if needed.

Purpose of the Study:

The purpose of this study is to learn about how asthma influences brain function, especially activation of a type of immune cell in the brain called microglia. We know that asthma causes airway inflammation.

This reaction may lead to chest tightness, coughing and wheezing. We are doing this study to better understand how airway inflammation affects the brain.

We will look at whether inflammation is related to symptoms of depression and anxiety. We will also look at whether inflammation affects things like memory or attention.

We hope this will help us understand how asthma affects brain health and long-term risk for dementia.

Severe Asthma and Non-Asthma Participants Needed

What are some reasons I may – or may not – want to be in this study?

You MAY want to be in this study if you are:

• Comfortable having researchers ask questions about your health.
• Willing to have an IV placed in your arm for a PET/MRI scan done for research purposes.
• Willing to allow your blood and sputum to be used for research purposes.
• Interested in contributing to scientific knowledge.

You may NOT want to be in this study if you:

• Know you are claustrophobic in MRI scanners.
• Are not able to HOLD your asthma medications prior to study visits.
• May not have time for two short study visits (1-2 hours) and one long study visit (7 hours).

Inclusion criteria:

• 18 to 75 years old
• Nonsmoker
• Have severe asthma
• Do not have asthma

Number of visits: 3

Compensation: up to $210

Study duration: up to 2 weeks

Procedures: The research team will ask you to come to our research center located within the UW Hospital and Clinics building for 3 visits. You will complete questionnaires, computer tasks, allergy skin test, and breathing tests. You will give a sputum sample once, and you will give a total of two blood samples. You will also complete brain imaging scans including PET/MRI and a separate MRI only scan.