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Center for Healthy Minds

University of Wisconsin–Madison
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Understanding the Mechanisms of Well-Being Training in Adults with and without Asthma

Image by weerapatkiatdumrong via iStockPhoto

Led by a team of researchers belonging to the Wisconsin Center for the Neuroscience and Psychophysiology of Meditation, this study examines the impact of two common meditation practices: mindfulness meditation and loving-kindness meditation, also called compassion meditation. The study gathers data from approximately 270 participants from three groups: long-term meditators, participants with no previous meditation experience and participants with no previous meditation experience who also have asthma.

Participants with no previous meditation experience are randomly assigned to a Mindfulness-Based Stress Reduction (MBSR) class, a health and well-being class, or a wait-list control group. Participants with asthma will be randomly assigned only to MBSR or a wait-list control group. Participants will complete many of the same measures throughout the course of the study, which will afford Center researchers and colleagues a comprehensive view of changes produced specifically by meditation practice, changes associated more generally with interventions designed to promote well-being and changes that may be the result of repeating tests across multiple occasions. The inclusion of both novice and experienced meditators provides a wide range of meditation practice experience within the study, allowing scientists to explore dose-related effects.

Project 1

Led by Center Founder Richard Davidson, this project focuses on the impact of mindfulness and compassion/loving-kindness meditation on neural, biobehavioral and hormonal indices of emotional reactivity and regulation. It includes a series of sub-projects focused on affective coloring, emotional anticipation and brain structural changes, with methods such as resting state and task-related fMRI, structural MRI, facial EMG and salivary cortisol.

Project 2

Asthma is a chronic disease that affects 7 to 10 percent of adults in the United States, according to the Centers for Disease Control and Prevention. Asthma causes substantial impairment that is reflected in the tens of millions of missed days of work as well as numerous doctor and emergency room visits annually. Individuals with asthma are twice as likely to develop depression and anxiety, which are associated with more frequent and severe asthma symptoms, especially for those under chronic stress.

Led by Center Scientist Melissa Rosenkranz, this project investigates the brain and periphery pathways to understand how psychological factors contribute to the expression of asthma symptoms. In addition, the study examines the effectiveness of meditation training in reducing airway inflammation in asthmatic individuals through reducing the reactivity of emotion-related neural circuitry in the brain.

Project 3

Led by UW–Madison Scientist and Center Collaborator Giulio Tononi, this project explores the relationship between meditation-induced changes in brain activity during sleep and brain activity and cognitive function during wakefulness. Center scientists and colleagues are examining whether previously reported increases in gamma oscillations during Non-REM (NREM) sleep in meditators are associated with changes in mental activity during sleep.

Special thanks to the collaboration of the UW Asthma and Allergy Clinic and the Center for Sleep and Consciousness and Wisconsin Sleep, including Gina Crisafi, Michelle Wolff, Melanie Boly, Stephanie Jones, Brady Riedner and Rick Smith

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The The Well-Being Study is actively recruiting.
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People Working on This Study

Nagesh Adluru
Nagesh Adluru
Assistant Scientist, Center for Healthy Minds
Gina Bednarek
Gina Bednarek
Associate Research Specialist, Center for Healthy Minds
William Busse
William W. Busse
Professor of Medicine, Section of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin–Madison
Kara Chung
Kara Chung
Research Intern, Center for Healthy Minds
RichardDavidsonDirectory
Richard J. Davidson
Founder, Center for Healthy Minds & Healthy Minds Innovations, William James & Vilas Professor of Psychology & Psychiatry
Daniela Dentico
Daniela Dentico
Assistant Scientist, Center for Healthy Minds
Robin Goldman
Robin Goldman
Assistant Scientist and Scientific Co-Director, Center for Healthy Minds
DanGrupe
Dan Grupe
Assistant Scientist, Center for Healthy Minds
JeanneHarris
Jeanne Harris
Research Specialist, Center for Healthy Minds
ChrisHarty
Chris Harty
Associate Research Specialist, Center for Healthy Minds
Ted Imoff Smith
Ted Imhoff-Smith
Research Specialist, Center for Healthy Minds
Regina Lapate
Regina Lapate
Postdoctoral Fellow, UC-Berkeley
Abby Lindemann
Abby Lindemann
Postdoctoral Research Associate
Antoine Lutz
Antoine Lutz
Senior Scientist, Center for Healthy Minds
Elizabeth Nord
Elizabeth Nord
Research Specialist, Center for Healthy Minds
Walker Pendersen
Walker S. Pedersen
Postdoctoral Research Associate, Center for Healthy Minds
ElenaPatsenko
Elena Patsenko
Research Scientist, Center for Healthy Minds
Melissa Rosenkranz
Melissa Rosenkranz
Associate Scientist, Center for Healthy Minds
Jane Sachs
Jane Sachs
Research Program Manager, Center for Healthy Minds
Giulio Tononi
Giulio Tononi
Professor of Psychiatry, University of Wisconsin–Madison
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